Latrunculin B Reduces Intraocular Pressure in Human Ocular Hypertension and Primary Open-Angle Glaucoma
نویسندگان
چکیده
منابع مشابه
Latrunculin B Reduces Intraocular Pressure in Human Ocular Hypertension and Primary Open-Angle Glaucoma.
PURPOSE To evaluate the safety, tolerability, and intraocular pressure (IOP)-lowering effect of Latrunculin-B (Lat-B), a marine macrolide that disrupts the actin cytoskeleton, in patients with ocular hypertension (OHT) or early primary open-angle glaucoma (POAG). METHODS In this Phase I, multicenter, double-masked, randomized, placebo-controlled, ascending-dose study, subjects with bilateral ...
متن کاملIncident open-angle glaucoma and intraocular pressure.
PURPOSE To evaluate the role of baseline intraocular pressure (b-IOP) as a risk factor for incident open-angle glaucoma (OAG) in participants of African origin from the Barbados Eye Studies. DESIGN Population-based 9-year cohort study. PARTICIPANTS Three thousand two hundred twenty-two persons examined during the study period who were free of glaucoma at baseline and at risk of developing O...
متن کاملPrimary open angle glaucoma and intraocular pressure in patients with systemic hypertension.
OBJECTIVE To investigate the association between Primary Open Angle Glaucoma (POAG), Intraocular Pressure (IOP) and systemic hypertension. DESIGN Cross-sectional, convenient and controlled study. SETTING Eye Clinic of the Lagos University Teaching hospital, Idi-Araba, Lagos, Nigeria. SUBJECTS Consecutive newpatients with documented history of hypertension medication of over three months a...
متن کاملFixed Combination of Travoprost and Timolol Maleate Reduces Intraocular Pressure in Japanese Patients with Primary Open-Angle Glaucoma or Ocular Hypertension: A Prospective Multicenter Open-Label Study
INTRODUCTION The efficacy of lowering intraocular pressure (IOP) and safety of switching to travoprost/timolol fixed combination ophthalmic solution (Duotrav(®), Alcon Laboratories, Inc., Fort Worth, TX, USA) in patients with primary open-angle glaucoma, normal tension glaucoma or ocular hypertension undergoing prostaglandin analog (PGA) monotherapy was investigated. METHODS Patients treated ...
متن کاملFixed combination of travoprost and timolol maleate reduces intraocular pressure in Japanese patients with primary open-angle glaucoma or ocular hypertension: analysis by prostaglandin analogue
BACKGROUND We have shown a decrease in mean intraocular pressure (IOP) by switching to travoprost/timolol fixed combination (TTFC) in subjects receiving prostaglandin analogue (PGA) monotherapy and requiring additional medication in a previous report. For analyzing factors affecting IOP reduction, baseline IOP and preceding PGA were selected as statistically and clinically significant factors. ...
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ژورنال
عنوان ژورنال: Translational Vision Science & Technology
سال: 2014
ISSN: 2164-2591
DOI: 10.1167/tvst.3.5.1